SB 203580

SB 203580^[1]

IUPAC name 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
Other names RWJ-64809;
Identifiers
CAS number	152121-47-6^Y
PubChem	176155
ChEMBL	CHEMBL10^N
Jmol-3D images	Image 1
SMILES CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Properties
Molecular formula	C₂₁H₁₆FN₃OS
Molar mass	377.43 g/mol
Appearance	White to off-white solid
Solubility in DMSO	50 mg/mL
Hazards
R-phrases	R22 R41
S-phrases	S26 S39
Main hazards	Xn
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

SB 203580 is an inhibitor of MAP kinase reactivating kinase.^[2] It suppresses the activation of MAPKAP kinase-2 and inhibits the phosphorylation of heat shock protein 27.

References

^ SB 203580 at Sigma-Aldrich
^ Cuenda, Ana; Rouse, John; Doza, Yair N.; Meier, Roger; Cohen, Philip; Gallagher, Timothy F.; Young, Peter R.; Lee, John C. (1995). "SB 203580 is a specific inhibitor of a MAP kinase homolog which is stimulated by cellular stresses and interleukin-1". FEBS Letters 364 (2): 229–33. doi:10.1016/0014-5793(95)00357-F. PMID 7750577.